Comprehensive analysis of serum concentration of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinase 1 in preschool children suffering from recurrent respiratory infections

Purpose - to systematically examine the state of interrelatedness between serum concentration matrix metalloproteinase 1 and tissue inhibitor 1, frequency acute respiratory infections (ARIs), a heterogeneous set other clinical laboratory parameters in preschool children. Materials methods. Forty children (21 boy 33 girls) aged 6 years old, undergoing inpatient treatment on infection, were involved study. They studied concentrations MMP-1 TIMP-1, C-reactive protein, certain blood leukocyte fractions, erythrocyte sedimentation rate, content several macro- microbiological elements their hair as well number signs. Also, two integral indicators ARIs recurrence calculated, namely, infectious index (InI) resistance index, indices inflammation dolichostenomelia. The statistical processing primary digital material obtained was performed by IBM SPSS Statistics 27 licensed program. Results. younger had higher (p=0.007) MMP-1/TIMP-1 ratio (p=0.008) compared older girls showed values (p=0.012) than boys. strong positive correlation InI (ρ=0.514; p=0.001; 95% CI [0.232; 0.716]) demonstrated. Using ordinal logistic regression method, significant simultaneously multidirectional dependence categorical (B=1.078; p=0.013; [0.223; 1.933]) age category examined (B=-1.942; [-3.757; -0.126]) established. Conclusions. It is assumed that more frequent are accompanied levels MMP-1. not unlikely there differential «tuning» activity response varying during previous year. degree influence predictor, namely MMP-1, models determined both significance this predictor variant its combination with covariates. study conducted accordance principles Declaration Helsinki. protocol approved local ethics committees institutions mentioned paper. An informed parental consent for No conflict interests declared authors.